FIVBVolleyball: We now focus on match with China, says USA coach: Ningbo, China, June 30, 2012 - With an easy 3-0 win over Cuba,... http://t.co/b5p8M6Yc

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Source: http://twitter.com/FIVBVolleyball/statuses/219011875420114944

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CNBC: Murdoch on News Corp.'s breakup, successors

On the day that the company?s board of directors OK?ed the move to divide it into two units, Chairman Rupert Murdoch tells CBNC?s David Faber in an exclusive interview? that he?ll be an active Chairman in the new companies. He also says it remains to be seen if his children will want to fully take the reins of the businesses after he steps down.

Source: http://marketday.msnbc.msn.com/_news/2012/06/28/12460712-cnbc-murdoch-on-news-corps-breakup-successors?lite

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Road congestion hurts jobs in Fairfax

Welcome to your Personalized User Bar. Here, you can manage your account, sign up for newsletters, navigate to site sections, and share interesting content on social networks. You also can receive alerts on upcoming events, new products, or subscription/account activities.

Source: http://feedproxy.google.com/~r/vertical_61/~3/FYVdy4V2zsE/road-congestion-hurts-jobs-in-fairfax.html

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Forty's a crowd

Public release date: 28-Jun-2012
[ | E-mail | Share ]

Contact: Kristin Kessler
krk@stowers.org
816-926-4139
Stowers Institute for Medical Research

'Paper of the week' shows that a master regulator protein brings plethora of coactivators to gene expression sites

KANSAS CITY, MOMolecular geneticists call big boss proteins that switch on broad developmental or metabolic programs "master regulators," as in master regulators of muscle development or fat metabolism. One such factor, the Activating Transcription Factor 6? (ATF6?) protein, takes charge following a cellular crisis known as endoplasmic reticulum (ER) stress, which is triggered by the accumulation of misfolded and aggregated proteins.

Molecularly, the ER stress pathway is always poised for action. Inactive ATF6? is normally embedded in cellular membranes, but at the first hint of protein overload, its working end springs superman-like into the nucleus, binds DNA and kicks on a host of target genes whose job is to clear a protein logjam.

Now, in a study published in the June 29 issue of The Journal of Biological Chemistry, and selected as "Paper of the Week" by the journal's editors, a team led by Stowers investigators Ron and Joan Conaway reveal that unlike the real superman ATF6? does not work solo. Using the ATF6? target gene HSPA5 as a probe, they apply mass spectrometry analysis to show that ATF6? recruits a fleet of coactivators to assist in target activation.

"We knew that as a master regulator, ATF6? was needed to turn on downstream genes in the ER stress response," says Ron Conaway, Ph.D., who with Joan Conaway, Ph.D., is co-corresponding author of the study. "Our goal was to determine what ATF6? was bringing with it to these genes' control elements."

"By devising a clever mix of state-of-the-art mass spectrometry and good old-fashioned biochemistry, this study has revealed that ATF6? is a virtual magnet for a wide range of 'A-list' co-regulators," said Michael K. Reddy, Ph.D., who oversees transcription mechanism grants at the National Institutes of Health's National Institute of General Medical Sciences, which partly supported the work. "These co-regulators offer a large array of proteins to target in efforts to control the ER stress response and to treat diseases that result from misfolded proteins."

That task of identifying co-regulators was challenging: labor-intensive molecular techniques the group applied to identify candidate interactors early on were not sensitive enough. At that point, the Conaways turned to their frequent collaborators Proteomics' Center director, Michael Washburn, Ph.D., and Laurence Florens, Ph.D., who heads the Stowers proteomics cores. Both had helped develop a sensitive mass spectrometry approach that can detect protein-protein interactions in highly complex mixtures, a technology known as MudPIT.

The group then set up a test-tube comparison. They genetically engineered a strand of DNA flanking the HSPA5 target gene, the so-called "enhancer" region recognized by ATF6?. They then dipped two identical DNA test strips into respective pots of cellular extractsone containing ATF6? and one notreasoning that factors in the ATF6? entourage would be recruited to the first but not the second. They then applied a single run of MudPIT to identify each ATF6?-specific partner.

In short, they found that it takes not a village but a metropolis to activate an ATF6? target. Many proteins bound the enhancer in both samples, meaning either that they're just background, or else that they must bind DNA even when the gene is inactive. But more than 40 were present in about 5-fold excess only in ATF6??spiked samples, suggesting they are tethered to the enhancer by ATF6?.

Among the latter were components of a multi-subunit behemoth protein known as Mediator, which bridges specific genetic switches (like ATF6?) and the catalytic machinery that copies a gene. Other proteins recruited by ATF6? through overlapping but not identical domains belonged to other large complexes known as SAGA and ATAC, which enzymatically relax chromosome structure to allow gene expression.

Researchers know that all DNA-binding factors partner with other proteins to switch genes on or off. What is remarkable here is their sheer number. "It would be very interesting to find out whether this is the norm," says Ron Conaway. "This work raises a ton of little questions about mechanism."

Among them is how do ATF6?-interacting factors arrange themselves on the test strip, and does a single ATF6? bind to all of them at once? "There are three separate ATF6? binding sites on the HSPA5 enhancer and ATF6? itself forms a dimer," explains Dotan Sela, Ph.D., a Conaway lab postdoc and the study's first author, "So potentially within this region there could be as many six activation domains," he explains.

Solving these puzzles could reveal molecular targets for seemingly unrelated diseases. While a little ATF6? signaling is absolutely essential for cellular housekeeping, unrelieved ER stress is a hallmark of neurodegenerative conditions like Alzheimer's and Huntington's Diseases and is correlated with insulin insensitivity and type II diabetes.

A direct role for ATF6? in what some now call "misfolded protein diseases" is unclear. Nonetheless, the study suggests ways to dampen ER stress signaling molecularly. "We show that the Mediator is relevant to HSPA5 expression," says Sela. "So one way to keep ATF6? from turning on a gene might be to devise ways to block binding of the Mediator to ATF6?."

Joan Conaway also points out that MudPIT data analysis does not require previous identification of a "suspect." "Our approach complements methods that test candidate interactors one by one," says Joan Conaway. "Because the analysis is unbiased, it could reveal novel proteins interacting with a particular enhancer, which then could be confirmed using other methods."

The Conaways began their pioneering studies of mammalian gene expression over three decades ago, when only laborious biochemical techniques were available. As a result, both deeply appreciate what a technological leap the current work represents. "This study provides proof of principle for the utility of mass spectrometry in defining novel transcriptional activators," says Ron Conaway. "We want to compare this data with that from other activatorsit's what we will be working on in the future."

###

In addition to Washburn and Florens, Lu Chen of the Conaway lab and Skylar Martin-Brown of the Washburn lab also contributed to the work.

Funding for the study came from the Stowers Institute for Medical Research, the National Institute of General Medical Science (GM041628) and the Helen Nelson Medical Research Fund at the Greater Kansas City Community Foundation.

About the Stowers Institute for Medical Research

The Stowers Institute for Medical Research is a non-profit, basic biomedical research organization dedicated to improving human health by studying the fundamental processes of life. Jim Stowers, founder of American Century Investments, and his wife, Virginia, opened the Institute in 2000. Since then, the Institute has spent over 900 million dollars in pursuit of its mission.

Currently, the Institute is home to nearly 550 researchers and support personnel; over 20 independent research programs; and more than a dozen technology-development and core facilities.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 28-Jun-2012
[ | E-mail | Share ]

Contact: Kristin Kessler
krk@stowers.org
816-926-4139
Stowers Institute for Medical Research

'Paper of the week' shows that a master regulator protein brings plethora of coactivators to gene expression sites

KANSAS CITY, MOMolecular geneticists call big boss proteins that switch on broad developmental or metabolic programs "master regulators," as in master regulators of muscle development or fat metabolism. One such factor, the Activating Transcription Factor 6? (ATF6?) protein, takes charge following a cellular crisis known as endoplasmic reticulum (ER) stress, which is triggered by the accumulation of misfolded and aggregated proteins.

Molecularly, the ER stress pathway is always poised for action. Inactive ATF6? is normally embedded in cellular membranes, but at the first hint of protein overload, its working end springs superman-like into the nucleus, binds DNA and kicks on a host of target genes whose job is to clear a protein logjam.

Now, in a study published in the June 29 issue of The Journal of Biological Chemistry, and selected as "Paper of the Week" by the journal's editors, a team led by Stowers investigators Ron and Joan Conaway reveal that unlike the real superman ATF6? does not work solo. Using the ATF6? target gene HSPA5 as a probe, they apply mass spectrometry analysis to show that ATF6? recruits a fleet of coactivators to assist in target activation.

"We knew that as a master regulator, ATF6? was needed to turn on downstream genes in the ER stress response," says Ron Conaway, Ph.D., who with Joan Conaway, Ph.D., is co-corresponding author of the study. "Our goal was to determine what ATF6? was bringing with it to these genes' control elements."

"By devising a clever mix of state-of-the-art mass spectrometry and good old-fashioned biochemistry, this study has revealed that ATF6? is a virtual magnet for a wide range of 'A-list' co-regulators," said Michael K. Reddy, Ph.D., who oversees transcription mechanism grants at the National Institutes of Health's National Institute of General Medical Sciences, which partly supported the work. "These co-regulators offer a large array of proteins to target in efforts to control the ER stress response and to treat diseases that result from misfolded proteins."

That task of identifying co-regulators was challenging: labor-intensive molecular techniques the group applied to identify candidate interactors early on were not sensitive enough. At that point, the Conaways turned to their frequent collaborators Proteomics' Center director, Michael Washburn, Ph.D., and Laurence Florens, Ph.D., who heads the Stowers proteomics cores. Both had helped develop a sensitive mass spectrometry approach that can detect protein-protein interactions in highly complex mixtures, a technology known as MudPIT.

The group then set up a test-tube comparison. They genetically engineered a strand of DNA flanking the HSPA5 target gene, the so-called "enhancer" region recognized by ATF6?. They then dipped two identical DNA test strips into respective pots of cellular extractsone containing ATF6? and one notreasoning that factors in the ATF6? entourage would be recruited to the first but not the second. They then applied a single run of MudPIT to identify each ATF6?-specific partner.

In short, they found that it takes not a village but a metropolis to activate an ATF6? target. Many proteins bound the enhancer in both samples, meaning either that they're just background, or else that they must bind DNA even when the gene is inactive. But more than 40 were present in about 5-fold excess only in ATF6??spiked samples, suggesting they are tethered to the enhancer by ATF6?.

Among the latter were components of a multi-subunit behemoth protein known as Mediator, which bridges specific genetic switches (like ATF6?) and the catalytic machinery that copies a gene. Other proteins recruited by ATF6? through overlapping but not identical domains belonged to other large complexes known as SAGA and ATAC, which enzymatically relax chromosome structure to allow gene expression.

Researchers know that all DNA-binding factors partner with other proteins to switch genes on or off. What is remarkable here is their sheer number. "It would be very interesting to find out whether this is the norm," says Ron Conaway. "This work raises a ton of little questions about mechanism."

Among them is how do ATF6?-interacting factors arrange themselves on the test strip, and does a single ATF6? bind to all of them at once? "There are three separate ATF6? binding sites on the HSPA5 enhancer and ATF6? itself forms a dimer," explains Dotan Sela, Ph.D., a Conaway lab postdoc and the study's first author, "So potentially within this region there could be as many six activation domains," he explains.

Solving these puzzles could reveal molecular targets for seemingly unrelated diseases. While a little ATF6? signaling is absolutely essential for cellular housekeeping, unrelieved ER stress is a hallmark of neurodegenerative conditions like Alzheimer's and Huntington's Diseases and is correlated with insulin insensitivity and type II diabetes.

A direct role for ATF6? in what some now call "misfolded protein diseases" is unclear. Nonetheless, the study suggests ways to dampen ER stress signaling molecularly. "We show that the Mediator is relevant to HSPA5 expression," says Sela. "So one way to keep ATF6? from turning on a gene might be to devise ways to block binding of the Mediator to ATF6?."

Joan Conaway also points out that MudPIT data analysis does not require previous identification of a "suspect." "Our approach complements methods that test candidate interactors one by one," says Joan Conaway. "Because the analysis is unbiased, it could reveal novel proteins interacting with a particular enhancer, which then could be confirmed using other methods."

The Conaways began their pioneering studies of mammalian gene expression over three decades ago, when only laborious biochemical techniques were available. As a result, both deeply appreciate what a technological leap the current work represents. "This study provides proof of principle for the utility of mass spectrometry in defining novel transcriptional activators," says Ron Conaway. "We want to compare this data with that from other activatorsit's what we will be working on in the future."

###

In addition to Washburn and Florens, Lu Chen of the Conaway lab and Skylar Martin-Brown of the Washburn lab also contributed to the work.

Funding for the study came from the Stowers Institute for Medical Research, the National Institute of General Medical Science (GM041628) and the Helen Nelson Medical Research Fund at the Greater Kansas City Community Foundation.

About the Stowers Institute for Medical Research

The Stowers Institute for Medical Research is a non-profit, basic biomedical research organization dedicated to improving human health by studying the fundamental processes of life. Jim Stowers, founder of American Century Investments, and his wife, Virginia, opened the Institute in 2000. Since then, the Institute has spent over 900 million dollars in pursuit of its mission.

Currently, the Institute is home to nearly 550 researchers and support personnel; over 20 independent research programs; and more than a dozen technology-development and core facilities.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-06/sifm-fac062812.php

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Dr. Ewa Kleczyk on Business, the Pharmaceutical Industry and ...

InTech, in its mission to not only put the highlights on its open access, scientific books but on its perspective authors as well, talked to Dr. Ewa Kleczyk, author of the chapters ?Risk Management in the Development of New Products in the Pharmaceutical Industry? (from the book ?Risk Management Trends?, Giancarlo Nota, 2011), ?The Determinants of Corporate Debt Maturity Structure? (from the book ?Business Dynamics in the 21st Century?, Chee-Heong Quah, and Ong Lin Dar, 2012) and co-author with Darrell J. Bosch of ?Households? Preferences for Plumbing Materials? (from the book ?Corrosion Resistance?, Hong Shih, 2012).

Risk Management Trends

Dr. Kleczyk obtained her PhD in Economics from Virginia Tech in 2008 and is currently employed as the?Senior Director, Custom Analytics at ImpactRx (formerly TargetRx), firm that provides pharmaceutical and biotech companies with information regarding the criteria in product choice and adoption for their brands. Among other, Dr. Kleczyk has been awarded for her diligent work by Cambridge Who?s Who, TargetRx Excellence Award, the American Business Women?s Association and the National Association of Professional Women as Dr. Kleczyk has been known and praised for her engagement in promoting women in science.

We talked to Dr. Kleczyk about her career, her paper titled ?Risk Management in the Development of New Products in the Pharmaceutical Industry?, the controversial pharmaceutical research field in general and open access.

InTech: For how long have you been researching risk management in the pharmaceutical industry?

I have worked in the Pharmaceutical Consulting Industry for the past 6 years that includes working in the area of new product forecasting and risk management.

InTech: In your chapter ?Risk Management in the Development of New Products in the Pharmaceutical Industry? you state that deciding which new products to develop is a major challenge for many pharmaceutical companies with an excess of opportunities, but limited resources. Is it possible that these limited resources prevent some excellent new medicines to see the light of day and cure or relieve the symptoms of a certain population sub-group suffering from rare illnesses?

I think the current ways of selecting products has become subjective and cost driven, impacting negatively the types of products that are taken to the market. Some products should be brought to the market, but due to the scares resources and a number of potentially more profitable drugs in the pipeline, they might not be available for patient use.

For example, recently, Big Pharma has decided to decrease the research finding for neuroscience drugs, as they have high financial and time research costs. This unprecedented decision might result in inadequate treatments of the growing elderly population for diseases such as depression, sleep disorders, Alzheimer, and Parkinson.

?I think the current ways of selecting products has become subjective and cost driven, impacting negatively the types of products that are taken to the market.? ? Ewa Kleczyk

InTech: As you wrote, until the late 1980s, cash flows, expected returns, and net present value of income were the key variables in the decision-making process of the new drug development and investment. So according to your research, how have things changed?

The Consumer Theory and its research techniques have become an important part of the new product potential evaluation process. Understanding the product perceptions of potential consumer groups, their adoption speed and rate can help more precisely investigate the product uptake, as well as inform the investment decisions into the new drugs. However, this research should not be done in a vacuum, as this method only covers the demand aspect of the new product potential research. Joining this research with the Net Income Analysis would ensure looking at the production costs and risks, as well as the future potential sales of the product when available for use.

InTech: How would you like for your research to be perceived by risk assessment managers?

I would like my chapter to be viewed as helpful to the risk assessment managers in making new product decisions. Knowing the available evaluation methods of new product potential and knowing when to use each of the different technique should help the management in making their investment and research decisions.

?InTech: While researching this specific field, what information you came across which struck you the most?

The information that struck me the most while doing my research for this chapter was the small number of chemical molecules that become available for patient use. Only 1% researched molecules is brought to market. This finding underlines the importance of understanding the key issues of new product risk management to properly identify the chemical molecules for investment.

InTech: You are a successful researcher publishing articles in journals, books and lecturing at conferences. You are also socially active by encouraging women to pursue a career in fields such as mathematics, traditionally ruled by men. What is your perception of women in science today?

Women play a significant role in all areas in today?s world, including business, politics, academics, and sciences. It is very encouraging for many young women to know that they can be whoever they would like to be in their professional lives, as long as they work hard and are committed to their goals.

However, I think, we, the professional women, should continue mentoring and encouraging girls and young women to study mathematics, sciences, and economics, as the work is not done yet. In today?s world being a super model, reality star, and actress seems more interesting and appealing to many young women, due to greater public exposure and high financial rewards.

Promoting women in science

I think creating sponsorship or mentorship programs at educational institutions could help to promote women in sciences and business. In addition, the financial support many women receive to pursue education in these areas should continue to be distributed. The more support women get, the more likely they to follow their dreams, and become part of the scientific, political, and business cultures.

InTech: You published under the Open Access model. What is your personal opinion on unlocking scientific content to a wider audience then ever before, removing the barriers previously held by traditional scientific publishers?

Open Access Journals have revolutionized sharing of scientific information, and promoted innovation and timely dissemination of research results. Prior to the Open Access Journals, the publishing process was very lengthy, and able to reach only a limited number of readers. Today, within a couple of months (sometimes even a shorter time frame) information can be shared with a wide audience of readers. The timely research dissemination helps for quicker socialization of new concepts, as well as further improvements of researched topics.

InTech: Do you think Open Access is beneficial to all scientists and researchers?

I truly believe that the Open Access Journals are beneficial to all scientists and researchers. As mentioned above, the shorter time frame of research dissemination, and ability for sharing work with a greater audience, inspires innovation and collaboration within the scientific community. I would want to caution the journals though from publishing any documents they receive as a submission. Some of the published work is not to up to the research standards, impacting the credibility of these new venues. Greater oversight should be implemented to limit potentially low quality of work from publishing.

InTech: In terms of a more fertile, subsidised and collaborative scientific environment, how do you compare Northern America to Europe?

In the recent 30 years, the US has become the innovation centre for technology and sciences. Researchers from all over the world arrive to the US to participate in research opportunities provided by the US government as well as private companies. I believe this level of involvement is not seen in the continental Europe, although in order to compete with the US innovation, the European Union has increased research funding for European researchers to retain current and attract new talent.

InTech: What are your impressions on InTech as your Open Access publisher?

I think InTech is a respectable venue for all authors to publish their work in, and receive world-wide exposure to their research. I was very happy to see the number of scientists from different countries contacting me about my work, and sharing their perspectives on the risk management subject.

InTech: Are you satisfied with the editor?s work, the management of the publishing process and the InTech?s publishing team?

I had a wonderful experience working with the InTech Team. The attention to detail and professionalism has made the process quite simple and enjoyable. Overall, I am very delighted by the process of publishing with InTech, and have already submitted another chapter for review.

InTech: Tell us something about your future plans.

In 10 years from now, I would like to lead a market research / consulting company. Even with increased technology, informative data analysis is a necessity to making the optimal decisions for any business. With declining budgets, making the right decision has become even more important, consequently having a highly qualified team, working to help clients finding the right solutions for their business needs, will help to save money, and increase profitability of the company.

About Dr. Ewa Kleczyk:

Dr. Ewa Kleczyk

Dr. Kleczyk serves as the Senior Director, Custom Analytics at ImpactRx (formerly TargetRx). She received her PhD in Economics from Virginia Polytechnic Institute and State University in 2008, and she is a member of the Who is Who, Healthcare Business Women Association, and Eastern Economic Association. She has given presentations at several conferences including Pharmaceutical Business Intelligence Research Group and Global Conference on Business and Economics and has been published in peer and non-peer reviewed journals including Journal of Medical Marketing, Marketing Bulletin, and International Journal of Business & Economics. Dr. Kleczyk began working for TargetRx as an econometrician, and was thereafter promoted to the Director position.

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Springpad turns Facebook ?likes? into real-life recommendations

Springpad, a digital notebook that lets you collect content online (like popular pinboard site Pinterest)?and organize it in a meaningful way (like Evernote), announced new Facebook integration features today that will make sharing interests easier than ever for its 3 million users.

Users can now import Facebook ?likes? into Springpad notebooks. The app already separates your collected items into categories like movies, music, bars, and recipes, and it will categorize and share your ?likes? in the same way. Followers and friends will then be able to reference the things you like as a decision making and discovery tool.

?Facebook ?likes? can be valuable for people seeking recommendations from friends who share similar interests, but today they?re not discoverable,? said Jeff Chow, CEO and cofounder of Springpad.

The new Facebook integration allows new users to automatically import their ?likes? into the app and have them categorized into notebooks. Springpad will then enhance the ?likes? by supplementing them with actionable information, like Rotten Tomato movie reviews, maps, and OpenTable reservation links. Users will also be able to post notebooks to their Facebook timelines if they choose.

When Springpad 3.0 launched in April, it added ?Explore? and ?Following? tabs to allow people to share their notebooks. Creating notebooks became more than a solitary activity. With the new features, ?likes? are no longer a simple expression of goodwill, but rather a testament to your unique tastes and interests.

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Live blog: Flagstaff Fire one ridge away from entering Boulder ...

Posted on: 3:21 pm, June 26, 2012, by Web Staff, updated on: 01:05pm, June 27, 2012

Flagstaff Fire. June 26, 2012.

Live Blog: Hit refresh for updates

Official updates from Boulder Office of Emergency Management

June 27 12:30pm: Officials are requesting that residents who live in pre-evacuation areas and whose property backs to Open Space turn on their sprinklers as soon as possible and leave them on. While the fire is not threatening homes or structures at this time, turning the sprinklers on will help homeowners create defensible space around their houses. This will help?firefighters if the fire continues to burn eastward.

June 27 9:30am: Information about donating or volunteering to help fire victims or firefighting efforts: HelpColoradoNow.org. You can also call 211 in your community.

June 27 9:20am: Boulder cancels Fourth of July fireworks in wake of Flagstaff Fire, dry and hot conditions.

June 27 8:20am: Fire had very little growth overnight. Aerial attack started at 8 a.m. with seven aircraft including five tankers. 250 personnel from 32 agencies are on scene. They will focus on public safety, structure protection and building fire lines on the southwest side of the fire today. Officials say if an evacuation order goes out, people are expected to leave immediately. More news briefing highlights:

• Fire is 1 1/2 miles from Boulder city limits
• No homes are immediately threatened
• Officials concerned about weather today? possibility of thunderstorms could bring wind that would negatively impact aerial attack
• 28 homes evacuated, nearly 2,500 pre-evacuation notices issued
• Conditions ?unprecedented? as far as dry weather is concerned

June 27 7:20am: For more information on evacuated animals and how you can help them, visit the Humane Society of Boulder Valley?s website.

June 27 7:17am: From Boulder County: Fire now estimated at 230 acres, according to infrared flyover. Still 0-percent containment.?250 firefighting personnel are working the fire from 50 agencies. Weather today calls for 15-20 mph winds with gusts of 25. Humidity is 15-20 percent and scattered thunderstorms are possible this afternoon.

June 27 6:40am:

• The fire is one ridge away from the city limits of Boulder
• The blaze is still 0-percent contained
• 200 people remain evacuated near Flagstaff road
• Some flames are visible from south Boulder
• An evacuation center is set up at New Vista High School at 700 20th Street near Broadway and Baseline Road.
• Media briefing scheduled for 8 a.m.
• Current temperature as of 6:40 am: 81 degrees. Wind gusts at 15 mph at that same time.

Flames visible from south Boulder early Wednesday

June 26 9:40pm:

• Only 26 homes have been evacuated near Bison Drive and Kossler Lake.
• A total of 2,416 reverse notifications have been sent to people in and around the affected area.
• Three helicopters and two tanker planes were working the fire until sunset.
• About 100 firefighters are on the ground doing structure protection through the night.
• The fire is burning in upper Skunk Canyon. just west of the NIST/NOAA campus, and expected to produce smoke in Boulder through the night.
• A Federal Type 1 team is expected to take over management of the fire on Wednesday.
• All Pets Animal Hospital, 5290 Manhattan Circle, 303-499-5335, is open 24 hours and is accepting small animals. In the case of an evacuation, small animals can be dropped off at All Pets if their owners are unable to take them with them in the case of an evacuation.
• No structures are threatened at this time.
• There are no reported injuries and there is zero percent containment of the approximately 300 acre fire.

June 26 9:23PM: #FlagstaffFire is burning in Upper Skunk Canyon, just west of NIST/NOAA, and expected to produce smoke in Boulder through the night. Only the original 26 homes that were evacuated near Bison Drive have been evacuated. A remaining 2,416 notifications were sent out to city residents near Flagstaff to remain on standby in case of a change in fire direction and behavior overnight. The Emergency Operations Center will remain open on a 24/7 basis until further notice.

June 26 8:15PM: Information about steps individuals can take to protect themselves from negative health effects related to the smoke is available at: http://www.bouldercounty.org/env/air/pages/wildfire.aspx

June 26 8:00PM: The Red Cross has closed the evacuation center at New Vista High School and established an evacuation center and overnight shelter at the East Boulder Community Center, 5660 Sioux Drive. People impacted by the fire who need information and/or a place to stay overnight are encouraged to go to that location.

June 26 8:00PM: Fire officials have provided an update on attack efforts. The fire has consumed an estimated 228 acres and is moving east in both the north and south directions. There are about 200 firefighters working this incident at this time from the following agencies: Rocky Mountain Fire, Coal Creek Fire, City of Boulder Fire, Boulder County Fire, Arapahoe and Roosevelt Forest Service, the Colorado State Fire Service, Lafayette Fire, Longmont Fire, Boulder Rural Fire, Boulder Emergency Squad and the Longmont Emergency Unit. The incident is currently being managed by the Boulder County Type 3 Incident Management Team.

Air attacks continue to be the primary strategy for as long as daylight remains. There are currently three Type 1 helicopters, one Type 3 helicopter, two heavy air tankers, a lead plane and an air attack plane working the fire.

A federal Type 1 team is expected to take over command sometime tomorrow morning.

June 26 7:48PM: The Red Cross has opened a shelter at the East Boulder Recreation Center, 5660 Sioux Drive, in Boulder, in response to the Flagstaff Fire. A full shelter team will be on site to help accommodate evacuees.

7:15PM UPDATE: Three spot fires are visible on the eastern side of the ridge behind NCAR. A task force of 40 firefighters are headed to the area of upper Table Mesa to attack these fires and create defensible space for homes and structures in the vicinity. Winds are now blowing to the northeast and have picked up in speed.

6:10PM UPDATE: The Emergency Operations Center has activated a call center for residents and others impacted by the fire to obtain information. The phone number is 303-413-7730. People seeking fire and evacuation information are encouraged to call this number. Individuals reporting new emergencies should continue to call 911. Media should continue to contact the media line. Any help getting this phone number out to the public is much appreciated.

6:01PM UPDATE: The City of Boulder has issued 1,485 additional pre-evacuation notices to phone numbers within city limits to include the Shanahan Ridge neighborhood. This is in addition to the 931 notices previously sent out. The current boundaries are Dartmouth to the north, Greenbriar to the south, Table Mesa and foothills on the west and Broadway on the east.

Residents in this area should begin preparing for possible evacuation orders. Gather up personal belongings and pets and stay tuned for additional instructions. An evacuation center has been established at New Vista High School at Broadway and Baseline.

In addition, the City of Boulder has announced that it is closing the pool at the South Boulder Recreation Center as a result of poor air quality caused by smoke. The recreation center itself remains open. For parents with children participating in summer camps, staff are continuing to monitor the situation and will issue e-mail updates as they become available.

5:19PM: City of Boulder spokeswoman: ?Now is the time to prepare?try to get what you can.? ?This fire has been moving very quickly.?

4:52PM: Pre-evacuation notices went out to 931 City of Boulder phone numbers. The area that received calls is bordered by Dartmouth on the north, Broadway on the east, all the way to the south edge of town. People should be ready to evacuate quickly. A Type 1 Federal Incident team is on its way.

4:48PM: Pre evacuations notifications issued for the City of Boulder. Dartmouth Ave on the north, west to Table Mesa and NCAR area east to Broadway.

4:35PM: Firefighting resources include 1 heavy air tanker, 3 Type 1 helis, 1 Type 3 heli, 4 Type 1 hand crews, 50 Firefighters

4:24PM: All open space and recreational areas from Eldorado Springs to Boulder Canyon are closed until further notice

Live Blog: Hit refresh for latest updates

4:12PM: All Pets Animal Hospital is taking small animals. 303-499-5335. 5290 Manhattan Circle.

4:08PM: NCAR is voluntarily evacuating

4:05PM: Evacuations have been ordered for residents southwest of Boulder as a new wildfire spreads through dense, rough terrain behind Boulder Mountain Park.

The Flagstaff Fire was estimated at 200-300 acres as of 4 p.m.

The Boulder County Sheriff?s Office has issued evacuation orders for approximately 26 households in the area of Bison Drive and Pine Needle Notch subdivision.

Road closures:

Bison Drive from 1000 block West

Flagstaff Rd. from Baseline & 6th Ave

An evacuation center is being established at New Vista High School at 700 20th Street near Broadway and Baseline.

On Twitter #FlagstaffFire

Official updates from Boulder Office of Emergency Management

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Road Freight in Dallas TX

Road Freight in Dallas TX can assist your small business are more useful, effective, and lucrative. Choosing the right strategies company is important if you need your small business to thrive within this fast-paced, highly-competitive business world. Logistics make any difference ? you simply can?t earn money unless of course your items reach your web visitors undamaged additionally, on occasion.

Strategic planning Issue

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Outsourced workers Scheduling details throughout Dallas TX 75205

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To be a small business, cost is more often than not a worry. In this kind of over-regulated, over-taxed, as well as very aggressive earth, searching for this particular affordable answers to your business wants is crucial to the health and profits of your respective company. To guide reduced the expense of your statigic planning operations, it?s a great conclusion for you to partner for some other enterprise when searching for Road Freight in Dallas TX. Almost all strategic planning suppliers platform their own prices upon volume, and joining up web-sites small company is just about the finest methods to lower your shipment charges.

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Road Freight in Dallas TX

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Business Organization Salary | ExpertsArticles.com

Generally, business enterprise managers oversee operations plus employees. Competition is more widespread for prime level careers because there are a reduced amount of them accessible. Depending on the size of the company, a variety of business administrators may be required. Some of the chores involved include planning, managing and linking a wide selection of expertise that enable friends to operate efficiently and effectively. They may be competent to oversee yourwants and conveniences of multiple departments and processes such as place requirements, deliver the results processes, pc services, files storage, appointment scheduling and supply. Some corporations require company managers that really help with complying and interior issues like insurance, federal government regulations, workplace safety requirements and devices.

Business management salary concentrations vary in line with the type of business, the level of accountability and the training level of a manager. The responsibility and capacity of an administrator also element heavily directly into salary. Pays are also determined by the number of several hours required. Most of business operators work a typical 40-hour week. The opposite half tend to be split somewhere between part-time and an around 40-hours work week.

In 2008, corresponding the the particular Bureau of Labor Statistics, the particular median business management income for management management jobs vary from $65,590 regarding state careers to $85,980 intended for larger company positions. Financial managers have a very median number of $77,280 to get credit relevant positions as many as $134,940 where investments and everything are involved.

Home business Management Pay (3)
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A top professional position are going to have a higher business enterprise management earnings per position because the assignments and nature of the get the job done are more sophisticated. These executives often do the job long hours, traveling frequently plus oversee big departments and operations. Formal education and learning of at least a bachelors level is the usual. The Business of Labor Studies reports business enterprise management pay levels ranged from a median amount of $158,560 up to a lot more than $1 million on an annual basis for high amount executive placements in large companies.

It is very important keep in mind that an organization management wages are a highly discussed item. With the manager?s education, higher level of experience, the organization size, in addition to responsibility plus authority, virtually all add up to a distinctive package. Regional area is a major component as well. There?s more levels of competition in New York City than a modest city for instance Ithaca so small business management staff are compensated appropriately.

Business executives will always be business management salary in high demand as corporations will always need them. Education and learning, credentials plus experience will propel business management salary specialists into operations positions using salaries like their skills.

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Buildings & Facilities Director ? Leading Telecoms Group ? Riyadh ...

Job Description

Our client is a leading Telecoms company in the Middle East. They have an outstanding reputation for delivering quality, innovation and reliability.
They work with international companies on special projects and have a large multicultural workforce

We are looking for an experienced DIRECTOR- Buildings and Facilities to join their team in Riyadh, Saudi Arabia.

OVERVIEW OF ROLE

Directly manages the strategic planning for the buildings and facilities section to continuously develop effective building projects and facilities maintenance operation management in order to attain high quality systems and standards. Directly oversee the management of all issues that pertains to building infrastructures, building facilities maintenance operations, repairs and renovations.

Manage the implementation of cost effective operating plans, process and procedures. Directs and contributes in designing company facilities, project implementation and commissioning, implementation of corrective and preventive facility maintenance to insure all aspects shall meet general specification in accordance with all standards. Leads and analyses problems and formulates alternative/innovative solutions to support the VP to achieve the section?s major objective and strategy plans.

Reporting to: Vice President ? Buildings and Facilities
KEY RESPONSIBILITIES

Department Strategy Formulation
? As a senior member of the Building and Facilities team contributes to the formulation and implementation of strategy and plans as appropriate for the department needs and objectives.
Department Management
? Manages the day-to-day operations of Buildings and Facilities and maintenance and facilities, providing expertise, encouraging and ensuring teamwork, aligning work process in order to achieve high performance standards, meet established targets, objectives and employee engagement in a motivated environment
? Exercises financial authority within established limits and controls departmental expenditure.
Project Team Leadership
? Leads and directs project teams compromising internal and contracted resources to maximize effectiveness to deliver projects on targeted time, costs and project/s standard quality.
Project Scope
? Defines and documents the project scope, project targets/objectives and high level project plans to translate desired business benefits into clear and achievable project objectives.
Maintenance Scope
? Oversees and directs the development and agreement to annual maintenance/ refurbishment plans and associated budgets
? Oversees and directs the buildings and facilities operation and repair and maintenance of all facilities and any other related support system, ensuring the best practice and standard are met
? Oversee and directs the implementation of preventive and corrective maintenance at all facilities
Resource Planning
? Prepares overall project resourcing and contingency plans to ensure effective individual project resourcing to meet all of the project objectives/ goals in all likely circumstances
Project Funding
? Oversee and directs the coordination with Finance to secure project funding and establish partnership enabling agreement to plan in line with strategic objectives of the company
? Financial budget planning, monitoring and cash flow
Pre-Qualification
? Oversee and directs line pre-qualification process to ensure that best possible resources are made available to company in a cost efficient and effective manner
Design Development
? Oversee and directs the supervision and participates in the development of conceptual and preliminary designs. Includes discussions with management to ensure they are satisfied with the proposed designs and that their requirements are being met

COMPENSATION & BENEFITS

? Should be used as a guide only and will reflect interview performance and experience levels
? As a guide, up to 40,000 SAR ? 50,000 SAR per month

Skills

ESSENTIAL REQUIREMENTS

? Bachelor?s Degree in Architecture or Civil Engineering in a known reputable College or University
? With post-graduate special training and seminars in the field of: Project Management and Building Facilities Operation and Maintenance
? 8 years of fulltime experience in Project management in a large organization specifically on technical aspect
? Good experience in various Engineering projects in direct implementation, design, supervision and building facility maintenance operations
? 5 ? 6 years fulltime experience in senior managerial level role
? Excellent knowledge in project management

KEY SKILLS

? Knowledge of floor plans, layouts, design software applications, engineering principles and standards
? Good knowledge in buildings and facilities operation and maintenance
? Good knowledge in tender procedures, vendor pre-qualification, consultant pre-qualifications
? Good knowledge in budget/financial planning, monitoring and cash flow
? Computer literate
? Advance level in English language
? Advance level in written and oral communications
? Good communication and interpersonal skills
? Good leadership skills
? Critical thinking and good analytical skills
? Well-developed managements skills
? Good organizational skills
? Time management skills
? Good negotiating skills

?

About This Company

International Executive Search & Selection Headhunting firm specializing in the Middle East

We work with local, Arabic speaking, Western and international mid-senior level management professionals who are looking for new opportunities.

We work with leading organizations across the GCC region and therefore have exclusive opportunities to suit the wealth of professional candidates we work with.

We have specialist Recruiters globally covering the following areas:
? Financial Services & Banking
? Sales, Marketing, PR & Branding
? HR, Talent Development & Recruitment
? FMCG, Food, Beverage & Manufacturing
? Legal, Compliance, Risk
? IT, ICT, Telecoms, Digital, Mobile & Technology
? Luxury Resorts & 5* Hotels
? Oil and Gas
? Construction, Engineering & Property Development
? Luxury Brands & Retail

With new roles coming in daily we can offer a premier service to our candidates and clients helping each achieve the desired outcome.
FIRST RESORT GLOBAL RECRUITMENT
Leaders in Executive Level Recruitment worldwide

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Wisdom from a Divorced Gal for You Marrying Types.

Or, as my friend,Christa, put it:?

Or sometimes you want to so badly because you know it's the only thing that will bring you any relief - just get it over with.

(Apologies from The Offbeat Drummer in advance about the highlighting and font clusterfuck. I can't figure out how to fix the html codes.)

Legitimate statistic? If you're planning on marrying, your literal chance of remaining married til death do you part is 50/50 in contemporary society. In America, anyway, marital longevity is the exception rather than the rule these days. In other words, we'll see a lot fewer 50th anniversary celebrations than in previous decades, like when most of our grandparents were alive.

You might remember several blogs back, when I analyzed Sternberg's Triangular Theory of love. (For a refresher course with impossible-to-see graphics that I've corrected below, see?http://www.theoffbeatdrummer.blogspot.com/2012/05/i-hate-to-use-journey-song-title-but.html.)?It looked something like this:?

Back in that blog, I noted that I knew too many married couples who had either settled into companionate love or worse yet, who had entered into the zone of empty love, where there was commitment, but the intimacy and passion were, by most accounts, gone. (Statistically, companionate love is the most commonly reported in society in long-term relationships.) I used the illustration of the ONLY famous case of consummate love that I could muster from the last century off the top of my head, that of John Lennon and Yoko Ono, who went through hell-and-gone to make things work, and did so successfully, until Lennon's murder in 1980.

It's not that I'm pro-divorce or anti-marriage. Either situation is a major life decision/change, and I've gained experience from both. Marriage can be wonderful and fulfilling, and divorce can be liberating and inherently really healthy, often in hindsight, and while painful in the moment, it's a decision most don't regret. ?I know a lot of relieved, happy divorced people who are either single (like me), separated and just waiting for the much-anticipated Day, (like Christa), or in happy post-divorce relationships that don't regret their decisions to have left their spouses (like my own ex-husband). I also know divorced people who, if they had to do it all over again, would never have left in the first place. From the still-married front, I know a few couples who seem on the perpetual brink of "Can we do a trial separation?" or "I think we need some space." Still others report being "happily" married, though that group, out of my entire social circle, is the smallest by far.

Hey, if you're shitpickles/gobbldygook about one another 20-30 years into your gig, then live your lives and God bless you. You're unusual, but lucky. If you're falling asleep on the couch and figure it's best to stay there until morning, yeah, well. If you're reduced to roommates who have a joint checking account but who mumble under your breath, "Oh, Christ, if he leaves his boxers crumpled up in the corner of the bathroom ONE MORE TIME!," or secretly grumble about another Sunday dinner with the in-laws, or you've turned into, basically, just friends, ?it's time to reconsider the state of your affairs at home.

What happens when you've been married for a decent span of time, you've bred children with your spouse, and then you find attracted to someone else and/or you just can't take the complacency or disinterest anymore? ?You do one of several things: 1) You own up to your feelings and have a frank discussion with your spouse, and you seek counseling to figure things out. (Which doesn't usually work, as I found out in my case and in the cases of a few divorced friends and family members of mine.) 2) You decide to stay for the sake of the kids. (Another REALLY bad idea, which breeds resentment and escalates existing frustrations. Toughing it out doesn't make you a martyr. It makes you both douchebags.) 3) You engage in an affair. (Which, while a sin and disavows the sacred commitment to your spouse that you took in front of GOD, nobody ever DIED AND WENT TO HELL as a result. You might even be new-agey enough to either tell your spouse about it (as I know in one case of a friend of mine) or don't make a concerted effort to hide your other relationship and get a subscription to Polyamory Today. 4) You follow your bliss, decide to figure your life out on your own, and split (WHICH, ACCORDING TO SOME RELIGIOUS DOCTRINES, IS ALSO A HUGE SIN, but again, it's doubtful anyone was poked into the bowels of Hades purely because the scarlet letter of "D" was embroidered onto their burning, disintegrating garments. (Bottom line in any event? Don't worry about the correlation between HELL and DIVORCE, despite what my own religion advises in a few paragraphs.)

If you're considering separation/divorce and you have no kids, you're pragmatically golden. Aside from asset-dividing, real estate headaches, reassigning your life insurance beneficiaries, separating your DVD collection, figuring out who gets the toaster oven (usually the guy, unless they're whizzes in the kitchen and are aces at whipping up food other than Stouffer's French Bread Pizzas, and finding an apartment, it's not all that different than the breakup of any other romantic relationship, regardless of duration. (It's safe to say that my breakup with Chris was like a zillion times more grueling, painful, difficult and lingering than the dissolving of my marriage to Craig, and I'd been with Chris for 3 1/2 years and Craig, including dating, at total of 15 years.)

When offspring are involved, it's markedly more grievously horrible to begin the separation/divorce process, particularly when you have to have "that talk" with your children. It's better if the other spouse actually tells the kids with you, but in my case, if was all up to me. ?It's easier when kids are either too young to really notice or remember that you were ever married in the first place or they're all grown up and busy leading their own lives, so they're like "Yeah, whatever, this is sad and weird but it beats you guys either fighting or ignoring one another all the time..." The worst is when they're of just enough emotional maturity to understand that the family is breaking apart and that life as they've always known it is ending, which is tantamount to a death in the family in many ways, but children take comfort in the fact that Mom and Dad BOTH still love them TONS and the adjustment to having two homes, albeit a lengthy and emotionally taxing recovery, does resolve itself eventually (as was the case with Luke). A tough key is convincing the kids that the divorce is in no way their fault, though there will be tantrums and days when the children wish to God they'd never been born in the first place, with the amount of utter crap your inability to stay married has piled upon them. Kids of a reasonable age and intellect will bitch about schlepping their belongings from house to house as per the custody agreement (if they're under 18), or if they're adults, feel pangs of guilt if it appears they're favoring one parent over the other, many of whom side with Mom regardless, unless Dad's been, categorically, the factor of stability to which they've become accustomed.

A lot of offspring see going to either Mom's or Dad's house as a staycation trip into Happy Ville. Pitted against one another, on occasion, one parent will make his/her house No Holds Barred Fun Zone, while the other parent's house is like being in prison. And kids are crafty. They like to do the pitting-against.

Something occurred to me yesterday: My wedding ceremony took longer than my divorce hearing in court, and in both cases, Craig and I shared a meal afterwards. A strange statistic, but I found it kind of ironic.

Recently, my mom and I were talking about my wedding gown being in the attic and what on Earth we're supposed to do with it. It's from 1996, en vogue back then, but not necessarily now, and it was a size 16, whereas now I'm a size 4. My mom had a dry cleaner "preserve" and box it up, you know, just in case. In case of what? I didn't breed a daughter. I don't plan on passing it down to Luke's eventual bride, and it's of no intrinsic value, other than sentimental. I divorced the guy--thus the gown is a largely-forgotten keepsake from 16 years ago.

Craig got custody of the wedding photo album ?(whereas, I got Luke's baby book and photo albums), and the only picture I have of me in my aforementioned gown, as you've seen before, is with my mom. It really was a gorgeous gown, not bad for waiting until 2 months before the big day to find a dress and buying it off the rack, which I spent $900 on, which either means it's appreciated, like my wedding rings, which I *don't* have custody of, or depreciated severely, like my car:

(Another thing I found when I moved back home? Craig's tuxedo bow tie/cumberbun set from our wedding, that I kept. THAT I'm holding onto. It was a John Lennon artwork, silk, limited-edition design of his naked John/Yoko embracing in color over black. I've looked on eBay many times, and on other web sites, and have never found another one like it. Even Google image searching for it comes up blank. But hey, if some rabid Lennon fan wants to give me like $500 for it, I might reconsider. Hey, times are tough.)


Pastor Dave is knee deep in wedding season, which keeps him mighty busy. Last night at church, during our prayers, we prayed for a couple he married yesterday and their burgeoning life together, after which Dave said a prayer for "all married couples" which, when he does that, drives me insane. We never pray for the single people in church--for God to send us a partner with whom to share our lives, which I think is unfair. Singles, by and large in our church, are ignored. There is no ministry for singles, the widowed or the divorced, while there are events (like dances) and symposiums for married and otherwise paired-up people. ?It's unfair that married people are looked upon as being more worthy of prayers and intercessions on their behalf than single or divorced folks are.?

In reading the by-laws of the Lutheran Church-Missouri Synod, it explicitly says the same thing the Scriptures say, which is that divorce is a no-no and anyone who remarries is committing adultery, and that committing adultery while you're with your first spouse casts you out with the lepers, in essence. That's bullshit, I say. While not as extreme as the Catholic church, in which you can't remarry in God's house because you're a general ex-communicated scumbag, you can re-marry in a Lutheran church. Still, it's evidently a sin to get divorced according to the Lutherans too. ?My church's official position is essentially this:

"Again, no exceptions are noted. The principle that to divorce one's spouse and?remarry is to commit adultery is presented by the Lord. In the second half of the?verse, we hear again (cf. Matt. 5:32) that for one to marry a divorced woman is to?commit adultery. We repeat here the grammatical point that the participle, without?the definite article, cannot be pressed to refer with absolute certainty to every?divorced woman. [66] Nor does the passage address in express words the case?of the remarriage of the spouse put away unjustly at another's initiative. These?qualifiers, however, in no way diminish the uncompromising character of the?Lord's requirement: divorce and remarriage are not in accordance with God's will?that marriage remain unbroken."

?Oh, there are by-laws concerning marrying someone who isn't a Christian in the first place, which breaks more of the church's laws. Evidently, God would strongly prefer you stay in a loveless, lifeless marriage with your fellow Christian than to get a divorce and actually have the capacity of building a strong, healthy relationship with someone else.?

Pfft.


If and when I do remarry, which seems iffy at best at this point, I doubt highly it'd be a service held in my church again; rather, it'd be in a neutral location (like Gibraltar!) with either Pastor Dave (I'd pay to fly him in) or a judge handling the service.


All this wedding/marriage nonsense is grating on my nerves as of late. Facebook friends celebrating anniversaries will post gooey love statuses honoring their spouses, their wedding pictures from like 15 years ago, or younger people, pictures of their engagement rings, and generally rub in the face their supposed happiness to anyone who might be single, widowed or divorced. Conversely, there are plenty of pages within social media dedicated to the upside of divorce and rubbing in the freedoms and lack-of-hassle therein. I?engage?in those pages when I'm feeling particularly crappy about being divorced (which mainstream society pushes upon us as a sub-group).?


It's widely judged that if you're the victim of one of two groups: You were dumped or you dumped your spouse. I admittedly dumped my husband and that was a lot as a result of my chronic substance abuse and mental illness, though I wasn't happy for a long time before that, which is probably why I started drinking in the first place, when my son was in preschool.?


We should all thank our lucky stars that in most states, anyway, there's now the "no-fault" divorce. See, both of my Miklasz grandparents were married and divorced before they married one another, in the 1920's. Back then, you had to have a reason. My grandfather's wife divorced him on grounds of drunkenness (in my family? What a surprise!) and my grandmother was sued for divorce by her first husband on grounds of desertion (she just split). There was no such things as "irreconcilable differences." And the stigma of divorce was so prevalent that it wasn't until my dad and uncle were adults that they even found out that their parents had been in first marriages, and that they had a half-sister somewhere, who was mentioned in my grandfather's will as being eligible to receive....NOTHING. (Which was really shitty...)


Divorce is certainly a very painful process for some, but for me it was liberatingly bittersweet and the resentment between my ex and I is very even-keeled at this point. He found himself a gal who'll tolerate his negative qualities even better than I did, and they seem really happy, which makes me really happy and is healthy for my son. I'm on an elective dating sabbatical, and have no plans to remarry in the next 5 years, which also makes my son happy.

I hope some of this clarifies the upside and downside of separation and divorce. It ain't easy, kids, but you'll be just fine. Someday, you too could be referred to as "(Insert Ex-Husband's first name here)' FIRST wife." And someday, it might not bother you anymore.

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Cervical Cells Most Vulnerable to HPV Are Identified

[unable to retrieve full-text content]Researchers have discovered the cervical cells targeted by HPV, raising new possibilities for preventing and treating cervical cancer.

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Video: Branches face off on Fast and Furious

A Second Take on Meeting the Press: From an up-close look at Rachel Maddow's sneakers to an in-depth look at Jon Krakauer's latest book ? it's all fair game in our "Meet the Press: Take Two" web extra. Log on Sundays to see David Gregory's post-show conversations with leading newsmakers, authors and roundtable guests. Videos are available on-demand by 12 p.m. ET on Sundays.

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What you should know about health care reform (CNN)

Share With Friends: | | Politics - Top Stories Stories, RSS and RSS Feed via Feedzilla.

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Antonio Villaraigosa On Mitt Romney: 'He Has Amnesia' (VIDEO)

Los Angeles Mayor Antonio Villaraigosa had some blunt words for Governor Mitt Romney on Sunday's "Face The Nation."

When asked about Romney's recent assertion that President Barack Obama had done "nothing" to advance comprehensive immigration reform, Villaraigosa retorted, "I think it's pretty clear that he has amnesia."

Villaraigosa went on to recall the President's stymied effort to pass the DREAM Act in 2010, explaining that a majority of Democrats in both the House of Representatives and the Senate voted in favor of the legislation but were defeated because the Senate needed 60 "yes" votes to overcome a Republican-led filibuster.

The President's deportation deferral program for young undocumented immigrants, Villaraigosa argued, is accomplishing what Congress should have done a long time ago.

Villaraigosa also had some advice for Romney, who is trailing Obama when it comes to support from Latinos: "If he wants to take [immigration] out of the debate in the campaign, he ought to call on Speaker Boehner and the Republicans in the House and Senate to work with President Obama and the Democrats to pass not only the DREAM act, but comprehensive immigration reform."

Romney has been under the microscope for his stance on immigration ever since Obama announced on June 15 that his administration would stop deporting young undocumented immigrations -- provided they meet certain qualifications. On last Sunday's "Face The Nation," Romney criticized Obama for failing to pass comprehensive immigration reform but declined to say where he'd overturn the President's recently-announced deportation deferral program.

Romney also repeatedly refused to address the question at the National Association of Latino Elected and Appointed Officials (NALEO) conference Thursday, saying only that his long-term solution would "supersede" the President's measure.

Villaraigosa was one of several Californians selected by Obama to be a national co-chair for his re-election campaign. The position involves advocating on behalf of the President, motivating voters and advising the campaign, reports the Los Angeles Times.

He was also named chairman and official spokesperson for this summer's Democratic National Convention.

Related on HuffPost:

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Blazing Sun Run aims to help troops overseas

Don't worry if you did not hear the news about Paraguay impeaching its president.

After all, it happened so fast that even Paraguay's neighbors are figuring out how to react.

Paraguay, the small South American nation known as an "island surrounded by...

Read More ?

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NoozhawkNews: Storified: Summer Solstice Parade on Noozhawk: Annual event is a sight to be seen ... as well as a scene http://t.co/fCJWd4l6

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Likuena players up in arms | Sunday Express

Mikia Kalati

MASERU ? Likuena players are up in arms against the Lesotho Football Association (Lefa) claiming that the embattled association owed them camping allowances.
The players claim that Lefa had not fulfilled its promise to pay them camping allowance after their goalless encounter with Sudan a fortnight ago.
Lefa, the players complain, have only paid them M1 300 each in bonuses raised through the gate takings.
Players who spoke to the Sunday Express on condition of anonymity for fear of reprisal said they have appealed to Lefa to take their welfare seriously.
?We are yet to receive our camping allowances that were supposed to have been given to us last Monday and no clear explanation was made to us,? said one of the senior players.
The players appealed to the football governing body to respect and take their welfare seriously if the team is to perform well.
?Our well being as players should always be made first priority, we deserve to be treated with respect as it is done in other countries, otherwise the team will forever be under performing,? he said.
Players? complained two days after concerned supporters of the national squad, Likuena, held a protest march against Lefa.
On Thursday, a group of about 30 concerned supporters handed over a petition to Lefa demanding the entire executive committee to resign.
Their complaints were mainly on the welfare of the players and lack of clear policies regarding the allowances of players which have led to unnecessary dismissal of key players on the eve of important matches.
Lefa?s spokesperson, Baba Malephane, defiantly told the supporters that the executive committee would remain in office until the association holds the elective conference in August.
This paper has been reliably told that the senior players who took the association to task over bonuses and allowances will be axed in the coming matches.
The Lefa?s acting CEO, Mokhosi Mohapi, told the Sunday Express that the delay to pay camping allowances was caused by a mistake in the calculation when the payment was prepared.
?I had a meeting with some of the senior players to explain the situation to them and surely by next week they will get their allowances,? Mohapi said.
Meanwhile, the association also issued an apology to the newly appointed Sports Minister, Thesele ?Maseribane following last week comments by the executive committee member Thabo Pule in the Sunday Express over the withdrawal of the under 20 team Makoanyane XI from the upcoming Caf youth Under-20 champions qualifiers.
?With regards to the referred statement made last week, the Lesotho Football Association admits that there was a bit of negligence in the manner in which the matter was presented to the paper.
?The Lesotho Football Association however wishes to earnestly apologise to the Honourable Minister of Gender and Youth, Sports and Recreation Mr Thesele ?Maseribane and the Ministry of Gender and Youth, Sports and Recreation and the Lesotho Sports and Recreation Commission for whatever inconvenience that may have been or may be caused by the article,? a statement from Lefa said.
Pule, a member of the Lefa executive committee, has expressed his hopes that ?Maseribane?s appointment as sports minister is good for the financially troubled association.
Pule said he was hopeful that ?Maseribane would help end Lefa?s financial maladies.

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Palestinian village faces demolition by Israel

SUSIYA, West Bank (AP) ? Palestinians in this hamlet have clung to their arid acres for decades, living without proper electricity or water while Israel provides both to Jewish settlers on nearby hills. But the end now seems near for Susiya: Demolition orders distributed last week by the Israelis aim to destroy virtually the entire village.

Before it does, Israel could encounter an international complication: Several European countries, with traditional Israel ally Germany in the lead, have funded solar panels, wind turbines and wells to make life in area villages more bearable. A diplomatic incident may loom.

"They are turning us into refugees on our own land," said resident Mohammed Nawaja, principal of a 35-student elementary school that consists of four tents slated for removal.

Susiya is one of more than a dozen "unrecognized" Palestinian herding communities in the southern West Bank, a desert-like area close to the Green Line, Israel's pre-1967 war frontier with the West Bank, when it was ruled by Jordan. Its 160-odd residents live in shacks, caves and tents with cement-reinforced walls.

Israeli authorities say the structures are unlicensed. Residents and their supporters say Israel refuses to grant permits as part of a plan to clear the area for future territorial claims ? a charge Israel denies.

Activists say Israeli authorities have issued demolition orders in most of the hamlets over the years, but Susiya faces the most immediate risk of wholesale razing.

At the heart of the matter is the struggle over the 62 percent of the West Bank that remains under full Israeli control ? known as Area C. This area is home to more than 300,000 Jewish settlers, more than double the number of Palestinians living there. More than 90 percent of the West Bank's Palestinians live in the parts of territory adding up to 38 percent of the land, administered by the Palestinian Authority.

The division results from the 1990s autonomy agreements between Israel and the Palestine Liberation Organization. They were meant to be temporary and lead to a final deal on drawing the borders of a Palestinian state more than a decade ago. Negotiations repeatedly broke down, while the patchwork of jurisdictions in the West Bank remained.

Critics say Israel has blocked virtually all Palestinian development in Area C, while expanding the Jewish settlements there. Only 5 percent of Palestinian requests for building permits in Area C have been granted in recent years, said Alon Cohen-Lifshitz of the Israeli group Bimkom, which calls for fair planning practices.

Planning restrictions and demolition orders are part of a wider Israeli land grab, said Michael Sfard, an attorney for Israeli activists who have installed solar panels and wind turbines with German funding in 18 small communities in the southern West Bank.

"The federal government and its EU partners are watching the situation ... very carefully," said a German Foreign Ministry spokesman Wednesday, on customary condition of anonymity. "They are calling for safeguarding the German and international projects ... and are in close contact with the Israeli authorities."

Israel's Civil Administration, the branch of the military dealing with Palestinians in Area C, said it is working on more than a dozen master plans in the southern West Bank to regularize what it considers Palestinian squatters.

Maj. Guy Inbar, an Israeli spokesman, said some of the work is being held up because Palestinians are not cooperating. He said some of the Palestinians in the southern West Bank would be asked to move as part of such plans, but he declined to give details.

Qamar Assad, an attorney for Susiya, said the villagers have not been offered an alternate site.

Israeli government spokesman Mark Regev said Israel is ready to tackle the core issue of drawing the borders of a Palestinian state, which would also resolve the problems of Susiya and the entire settlement issue.

The Palestinians, who want a state in the West Bank, Gaza and east Jerusalem ? territories Israel captured in the 1967 war ? refuse to resume talks until Israel freezes settlement construction on occupied lands.

Susiya's defenders say it's more vulnerable to displacement than some of the other villages in the area. The village is flanked by a Jewish settlement and the ruins of a centuries-old Jewish town of the same name.

Susiya residents lived in the area of the ruins until it was declared an archaeological site and they were forced to leave in the mid-1980s. Some left for other Palestinian communities, while others settled a few hundred yards away, on land Nawaja says is privately owned by him and his relatives.

Since Israel did not recognize the community, it was not hooked up to electricity or water grids, while the settlement of Susiya and several unauthorized Jewish outposts in the area receive such services, said Sfard.

In 2010, Israel's government designated the Susiya excavation area as a Jewish heritage site and promised funding to turn it into a major tourist attraction. Susiya residents say they've been barred from visiting the site, even though some were born there.

Among the finds are the remains of a synagogue with elaborate floor mosaics, and explanations offered to visitors include many links between the apparent practices of town residents and those described in Jewish scriptures.

Israeli archaeologist Yonathan Mizrahi, who was not involved in the dig, said excavations also yielded remnants of a mosque built atop the synagogue in later years, but that this is not mentioned to visitors. "There is a clear political agenda, to legitimize the settlement (of Susiya) as continuing the Jewish presence of the past," he said.

Last week, Civil Administration inspectors distributed demolition orders for several dozen structures in the village, including the school, a makeshift clinic, residential tents, animal shelters and German-funded solar panels, Assad said.

Some of the orders were initially issued in the 1990s but not implemented, while others are new.

Inbar said Israel is in touch with German officials, and one proposal is to take the solar panels to another area if Susiya residents agree to move there. The German Foreign Ministry official did not address the issue publicly.

The Israeli group that installed the panels, Comet-ME, said demolition orders or their precursors, stop-work orders, have been issued against nine of their 18 sites, including Susiya. The group is providing electricity to 1,300 Palestinians in the area.

Comet-ME said it had hoped to set up six more installations this year but will have to stop work until the legal problems are solved.

___

Associated Press writer David Rising contributed to this report from Berlin.

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